GES-11, a Novel Integron-Associated GES Variant in Acinetobacter baumannii
نویسندگان
چکیده
منابع مشابه
GES-11, a novel integron-associated GES variant in Acinetobacter baumannii.
New extended-spectrum beta-lactamase GES-11 was detected in Acinetobacter baumannii BM4674. The enzyme conferred resistance to beta-lactams, including aztreonam, and reduced susceptibility to carbapenems. The structural gene was part of a class 1 integron borne by self-transferable plasmid pIP847. GES-type beta-lactamases have not been reported previously in A. baumannii.
متن کاملKinetic and crystallographic studies of extended-spectrum GES-11, GES-12, and GES-14 β-lactamases.
GES-1 is a class A extended-spectrum β-lactamase conferring resistance to penicillins, narrow- and expanded-spectrum cephalosporins, and ceftazidime. However, GES-1 poorly hydrolyzes aztreonam and cephamycins and exhibits very low k(cat) values for carbapenems. Twenty-two GES variants have been discovered thus far, differing from each other by 1 to 3 amino acid substitutions that affect substra...
متن کاملCarbapenem-hydrolyzing GES-type extended-spectrum beta-lactamase in Acinetobacter baumannii.
Acinetobacter baumannii isolate AP was recovered from a bronchial lavage of a patient hospitalized in Paris, France. A. baumannii AP was resistant to all β-lactams, including carbapenems, and produced the extended-spectrum β-lactamase (ESBL) GES-14, which differs from GES-1 by two substitutions, Gly170Ser and Gly243Ala. Cloning of the bla(GES-14) gene followed by its expression in Escherichia c...
متن کاملGES-type and OXA-23 carbapenemase-producing Acinetobacter baumannii in Turkey.
INSERM U914 ‘Emerging Resistance to Antibiotics’, Le KremlinBicêtre, France; Department of Infectious Diseases and Clinical Microbiology, Ege University Medical Faculty, İzmir, Turkey; Medical andMolecularMicrobiologyUnit, Department ofMedicine, Facultyof Science, University of Fribourg, Fribourg, Switzerland; Department of Medical Microbiology, Ege University Medical Faculty, İzmir, Turkey; In...
متن کاملDetection of multidrug-resistant Pseudomonas aeruginosa harboring bla GES-1 and bla GES-11 in Recife, Brazil.
INTRODUCTION Pseudomonas aeruginosa, an important pathogen globally, presents several resistance mechanisms. This study aimed to investigate the presence of bla GES in clinical isolates of Pseudomonas aeruginosa obtained from various clinical specimens from patients admitted to three different hospitals in Recife, Brazil. The Guiana extended spectrum beta-lactamase (GES) enzymes are responsible...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2009
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00072-09